Jews in Poland under Nazi occupation are confined to ghettos surrounded by barbwire and armed SS guards, while awaiting deportation to concentrations camps. The Warsaw Jewish Ghetto, one of the largest in the country, in 1943, is wrought with disease, starvation and a dwindling population. Knowing of their potential fate, ghetto residents form the Jewish Combat Organization (ZOB). After a number of Nazi soldiers are killed in a ZOB uprising in January of 1943, the Nazis decide to clear out the ghetto, sending 1000 SS troops to Warsaw in April of 1943. The ghetto eventually falls, more than 56,000 are killed, another 100,000 die of disease, and more than 300,000 Jews are sent to various concentration camps.